WeO-02

WeO-02

THE APPLICATION OF MS TO PROBE THE DEVELOPMENT OF BIOACTIVE PEPTIDES IN THE TADPOLE CYCLE OF Litoria splendida

Paul A. Wabnitz,^a John H. Bowie,^a Michael J. Tyler.^b

Departments of Chemistry^a and Zoology^b, The University of Adelaide, South Australia, 5005

The skin of the adult green tree frog Litoria splendida contains seven host defence peptides of which the major components are the hypotensive peptide caerulein (1) and the potent anti microbial agent caerin 1.1 (2).

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We were interested to determine whether these peptides occur also in the tadpole. The peptide profiles of tadpoles of L.splendida were monitored through its development cycle. The results indicated that the host defence peptides are present, but are found in a specific order.

THE APPLICATION OF MS TO PROBE THE DEVELOPMENT OF BIOACTIVE PEPTIDES IN THE TADPOLE CYCLE OF Litoria splendida

Paul A. Wabnitz,a John H. Bowie,a Michael J. Tyler.b

Departments of Chemistrya and Zoologyb, The University of Adelaide, South Australia, 5005

Paul A. Wabnitz,^a John H. Bowie,^a Michael J. Tyler.^b

Departments of Chemistry^a and Zoology^b, The University of Adelaide, South Australia, 5005